Clinical Manifestations, Blood Serotonin Level, Electroencephalography and Brain Magnetic Resonance Imaging in Autistic Children

The Aim of the Study: Identification of the common clinical manifestations and types of autism in children Identification if there is a correlation between the clinical manifestations and blood serotonin level, electroencephalography (EEG) changes, and Brain Magnetic Resonance Imaging (MRI) changes. Subjects Methods: Two groups of children were included in this study :The first group included autistic patients of various The second group included the control group: All children (cases and controls) were subjected to the following: History &examinations ,measurement of plasma level of serotonin, neurophysiological assessment by using conventional EEG Brain magnetic resonance imaging (MRI) Results: The study was carried out on 22 autistic children and 10 healthy control children matched for age and sex. Highly statistically significant difference between study groups as regard EEG abnormality which higher in patients than control group P < 0.01.Statistically significant difference between the studied children in frontal horn widths (P < 0.05).(Autistics were higher than controls). Statistically significant difference among study groups in diameter of inner table of clavrium (P < 0.05). Conclusion: Hyperactivity are a significant co-morbid conditions associated with autism. There is a positive correlation between epilepsy and severity of autism. There is high blood serotonin level in about one-third of autistic children with positive correlation between high serotonin level and severity of autistic features. There is a positive correlation between brain MRI measurement abnormalities and severity of autism. Fathi, m., afifi, shora, y., darwish, Hazem, h., el-khalegy, tarek, i., Menecie, Kamel, M., ewedi, mohammad Abdel hadi, mohey el-din Tharwat., Department of Neurology, Al-Azhar university, Cairo. Department of Clinical pathology, Al-azhar university, Cairo Conflict of interest: Non Financial grant : Non